Preimplantation testing for chromosomal disorders improves reproductive outcome of poor-prognosis patients
نویسندگان
چکیده
منابع مشابه
Controversy: Preimplantation Genetic Diagnosis
bjective: To review a 12-year experience of the world’s three largest preimplantation genetic diagnosis PGD) centers. esign: Multicenter analysis of the clinical outcome of PGD. etting: In vitro fertilization programs at the Reproductive Genetics Institute, Chicago, Illinois; Saint arnabas Medical Center, West Orange, New Jersey; and SISMER, Bologna, Italy. atient(s): Poor-prognosis IVF patient...
متن کاملWill preimplantation genetic diagnosis assist patients with a poor prognosis to achieve pregnancy?
PGD (preimplantation genetic diagnosis) of aneuploidy for chromosomes X, Y, 13, 18 and 21 was carried out on 196 embryos from 36 infertile patients classified with a poor prognosis due to (i) maternal age, (ii) repeated in-vitro fertilization (IVF) failures and (iii) mosaic karyotype. The percentage of abnormal embryos was comparable in the three groups of patients: maternal age 63%, repeated I...
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Background: Chromosome abnormalities are associated with poor morphology and development in human preimplantation embryos, all together lead to poor outcomes. This study aimed to explore altered expression of DNA damage pathways in “poor morphological and development embryos with sever aneuploidies”. Materials and Methods: Surplus day-4 embryos of PGD cases were pooled in two groups: Poor progn...
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PURPOSE The specific role of chromosomal instability (CIN) in tumorigenesis has been a matter of conjecture. In part, this is due to the challenge of directly observing chromosome mis-segregation events as well as the inability to distinguish the role of CIN, which consists of increased rates of chromosome mis-segregation, from that of aneuploidy, which is a state of nondiploid chromosome numbe...
متن کاملPredictors of Poor Prognosis in Aluminum Phosphide Intoxication
ABSTRACT Background: Aluminum phosphide as a fumigant is extensively used for wheat preservation from rodents and bugs especially in silos worldwide. There is increasing number of acute intoxication with this potentially lethal compound because of its easy availability. We have tried to locate predictors of poor prognosis in patients with aluminum phosphide intoxication in order to find patien...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2005
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)60961-3